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Article

Vaccine evaluation and genotype characterization in children infected with rotavirus in Qatar.

Pediatric research - 1 Aug 2023

Mathew Shilu, Al Khatib Hebah A, Al Ibrahim Malak, Al Ansari Khalid, Smatti Maria K, Nasrallah Gheyath K, Ibrahim Emad, Al Thani Asmaa A, Zaraket Hassan, Yassine Hadi M

Abstract excerpt

BACKGROUND: We characterized and identified the genetic and antigenic variations of circulating rotavirus strains in comparison to used rotavirus vaccines. METHODS: Rotavirus-positive samples (n = 231) were collected and analyzed. The VP7 and VP4 genes were sequenced and analyzed against the rotavirus vaccine strains. Antigenic variations were illustrated on the three-dimensional models of surface proteins....

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Identifiers

PMID: 36658331
DOI: 10.1038/s41390-023-02468-7
PMCID: PMC10382313

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