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Tideglusib enhances odontogenic differentiation in human dental pulp stem cellsin vitro

2 Dec 2022

Abstract excerpt

AIM: Tideglusib is a small molecule agonist of the canonical Wnt pathway. The present study investigated the influence of Tideglusib on human dental pulp stem cell (hDPSC) proliferation, apoptosis, migration and odonto/osteogenic differentiation. METHODOLOGY: hDPSCs were treated with 50, 100 nM or 200 nM Tideglusib. β-catenin accumulation was detected by immunofluorescence staining. Colony-forming unit ability...

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PMID: 36458950
DOI: 10.1111/iej.13877

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