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Article

Optimizing the screening of alpha-1 antitrypsin deficiency using serum protein electrophoresis.

Clinical chemistry and laboratory medicine - 23 Feb 2023

Wauthier Loris, Jacques Stéphanie, Delanghe Joris, Favresse Julien

Abstract excerpt

OBJECTIVES: Alpha-1 antitrypsin (A1AT) deficiency was first identified in patients with emphysema by the absence of the α1 band on serum protein electrophoresis (SPE). Today, capillary zone electrophoresis is widely performed in laboratories. Here, we compared two SPE systems to detect decreased A1AT concentrations to optimize their use as a screening tool for A1AT deficiency. METHODS: Serum protein...

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Identifiers

PMID: 36420543
DOI: 10.1515/cclm-2022-0967

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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