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Cancer-testis antigen lactate dehydrogenase C4 as a novel biomarker of male infertility and cancer

2 Nov 2022

Abstract excerpt

A unique lactate dehydrogenase (LDH) isoenzyme designated as lactate dehydrogenase C4 (LDH-C4) is found in mammalian mature testis and spermatozoa. Thus far, LDH-C4 has been well studied with regard to its gene and amino acid sequences, structure, biological properties, and peptide synthesis. Accumulating evidence has shown that LDH-C4 is closely related to spermatic energy metabolism and plays a critical role in...

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PMID: 36408133
DOI: 10.3389/fonc.2022.936767

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