Article
Capitalizing on paradoxical activation of the mitogen-activated protein kinase pathway for treatment of Imatinib-resistant mast cell leukemia.
Hematological oncology - 1 Aug 2023
Wilhelm Thomas, Toledo Marcelo A S, Simons Ilka, Stuth Christian, Mohta Vrinda, Mülfarth Ronja, Nitsche Marcus, Maschke-Neuß Karin, Schmitz Susanne, Kaiser Anne, Panse Jens, Christen Deborah, Arock Michel, Zenke Martin, Huber Michael
Abstract excerpt
Prevention of fatal side effects during cancer therapy of cancer patients with high-dosed pharmacological inhibitors is to date a major challenge. Moreover, the development of drug resistance poses severe problems for the treatment of patients with leukemia or solid tumors. Particularly drug-mediated dimerization of RAF kinases can be the cause of acquired resistance, also called "paradoxical activation." In the...
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