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Article

Shared genetic risk factors and causal association between psoriasis and coronary artery disease.

Nature communications - 2 Nov 2022

Patrick Matthew T, Li Qinmengge, Wasikowski Rachael, Mehta Nehal, Gudjonsson Johann E, Elder James T, Zhou Xiang, Tsoi Lam C

Abstract excerpt

Psoriasis and coronary artery disease (CAD) are related comorbidities that are well established, but whether a genetic basis underlies this is not well studied. We apply trans-disease meta-analysis to 11,024 psoriasis and 60,801 CAD cases, along with their associated controls, identifying one opposing and three shared genetic loci, which are confirmed through colocalization analysis. Combining results from...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 36323703
DOI: 10.1038/s41467-022-34323-4
PMCID: PMC9630428

Genes

CAD
IFIH1
IL23A

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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