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Article

Evaluation of Volumetric Bone Mineral Density, Bone Microarchitecture, and Bone Strength in Patients with Achondroplasia Caused by FGFR3 c.1138G > A Mutation.

Calcified tissue international - 1 Jan 2023

Liang Hanting, Qi Wenting, Jin Chenxi, Pang Qianqian, Liu Wei, Jiang Yan, Wang Ou, Li Mei, Xing Xiaoping, Pan Hui, Xia Weibo

Abstract excerpt

Achondroplasia (ACH) is a skeletal disorder caused by fibroblast growth factor receptor 3 (FGFR3) variants. Volumetric bone mineral density (vBMD), bone microarchitecture, and strength have not been evaluated in these patients previously. This study aims to evaluate vBMD, bone microarchitecture, and strength in ACH patients. Seventeen patients underwent clinical and biochemical evaluations, and genetic testing....

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PMID: 36261652
DOI: 10.1007/s00223-022-01027-2

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