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Article

Skeletal Characterization of the Fgfr3 Mouse Model of Achondroplasia Using Micro-CT and MRI Volumetric Imaging.

Scientific reports - 11 Jan 2018

Shazeeb Mohammed Salman, Cox Megan K, Gupta Anurag, Tang Wen, Singh Kuldeep, Pryce Cynthia T, Fogle Robert, Mu Ying, Weber William D, Bangari Dinesh S, Ying Xiaoyou, Sabbagh Yves

Abstract excerpt

Achondroplasia, the most common form of dwarfism, affects more than a quarter million people worldwide and remains an unmet medical need. Achondroplasia is caused by mutations in the fibroblast growth factor receptor 3 (FGFR3) gene which results in over-activation of the receptor, interfering with normal skeletal development leading to disproportional short stature. Multiple mouse models have been generated to...

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Identifiers

PMID: 29323153
DOI: 10.1038/s41598-017-18801-0
PMCID: PMC5765052

Genes

FGFR3

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