Article
GII.17[P17] and GII.8[P8] noroviruses showed different RdRp activities associated with their epidemic characteristics.
Journal of medical virology - 1 Jan 2023
Gao Junshan, Zhang Zilei, Xue Liang, Li Ying, Cheng Tong, Meng Luobing, Li Yijing, Cai Weicheng, Hong Xiaojing, Zhang Jumei, Wang Juan, Chen Moutong, Ye Qinghua, Ding Yu, Wu Qingping
Abstract excerpt
Norovirus is the primary foodborne pathogenic agent causing viral acute gastroenteritis. It possesses broad genetic diversity and the prevalence of different genotypes varies substantially. However, the differences in RNA-dependent RNA polymerase (RdRp) activity among different genotypes of noroviruses remain unclear. In this study, the molecular mechanism of RdRp activity difference between the epidemic strain...
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