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The acquisition of transferable extrachromosomal fec operon is associated with a cefiderocol MIC increase in Enterobacterales

28 Sept 2022

Abstract excerpt

BACKGROUND: Cefiderocol is a novel siderophore cephalosporin active against MDR Gram-negative bacilli, including MBL-harbouring Enterobacterales. The detection of multiple cefiderocol-resistant blaVIM-carrying Enterobacterales isolates (MIC = 4 mg/L) from a single patient suggested an additional, potentially transferable, resistance determinant as blaVIM typically does not elevate cefiderocol MIC above the...

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PMID: 36245258
DOI: 10.1093/jac/dkac347

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