Article
Impediments to Heart Transplantation in Adults With MELASMT-TL1:m.3243A>G Cardiomyopathy.
Journal of the American College of Cardiology - 11 Oct 2022
Di Toro Alessandro, Urtis Mario, Narula Nupoor, Giuliani Lorenzo, Grasso Maurizia, Pasotti Michele, Pellegrini Carlo, Serio Alessandra, Pilotto Andrea, Antoniazzi Elena, Rampino Teresa, Magrassi Lorenzo, Valentini Adele, Cavallini Anna, Scelsi Laura, Ghio Stefano, Abelli Massimo, Olivotto Iacopo, Porcu Maurizio, Gavazzi Antonello, Kodama Takahide, Arbustini Eloisa
Abstract excerpt
BACKGROUND: The heart is commonly involved in maternally inherited mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes (MELAS) syndrome caused by the MT-TL1 m.3243A>G mutation of the mitochondrial DNA. Heart transplantation (HTx) is controversial and has rarely been performed with conflicting results. OBJECTIVES: We analyzed factors preventing HTx in consecutive adult patients with...
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