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[Selection of mutants of Clostridium acetobutylicum defective in production of acetone].

Annales de l'Institut Pasteur. Microbiology - 1 Jan 2000

Janati-Idrissi R, Junelles A M, el Kanouni A, Petitdemange H, Gay R

Abstract excerpt

The butyrate analogue 2-bromobutyrate is toxic toward Clostridium acetobutylicum. After mutation using nitrosoguanidine, mutants resistant to the suicide co-substrate 2-bromobutyrate were selected. Such mutants no longer produced acetone, whereas the synthesis of butanol and ethanol was unaffected. Enzymatic analysis of a 2-bromobutyrate-resistant mutant showed a low level of coenzyme A transferase and of...

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PMID: 3620201
DOI: 10.1016/0769-2609(87)90119-0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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