Article
New methodology of TMB assessment from tissue and liquid biopsy in NSCLC.
PloS one - 1 Jan 2022
Křížová Ľudmila, Šafaříková Markéta, Kalousová Marta, Pfeiferová Lucie, Kuběna Aleš Antonín, Vočka Michal, Ulrych Jan, Franková Věra, Petruželka Luboš, Zima Tomáš, Feltl David
Abstract excerpt
Immunotherapy has dramatically influenced and changed therapeutical approach in non-small cell lung cancer (NSCLC) in recent five years. Even though we can reach long-term response to this treatment in approximately 20% of patients with NSCLC, we are still not able to identify this cohort of patients based on predictive biomarkers. In our study we have focused on tumor mutation burden (TMB), one of the potential...
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