Article
An Infant Case of Streptococcus Pneumoniae-Associated Thrombotic Microangiopathy with Heterozygous CFI Mutation and CFHR3-CFHR1 Deletion.
The Tohoku journal of experimental medicine - 25 Oct 2022
Matsumoto Yuji, Ikezumi Yohei, Kondoh Tomomi, Yokoi Katsuyuki, Nakajima Yoko, Kumagai Naonori, Kato Takema, Kurahashi Hiroki, Ito Tetsuya
Abstract excerpt
Thrombotic microangiopathy (TMA) is a disease that causes organ damage due to microvascular hemolytic anemia, thrombocytopenia, and microvascular platelet thrombosis. Streptococcus pneumoniae-associated TMA (spTMA) is a rare complication of invasive pneumococcal infection. In addition, atypical hemolytic uremic syndrome (aHUS) is TMA associated with congenital or acquired dysregulation of complement activation....
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