Article
Opportunities for improved clinical trial designs in acute respiratory distress syndrome.
The Lancet. Respiratory medicine - 1 Sept 2022
Wick Katherine D, Aggarwal Neil R, Curley Martha A Q, Fowler Alpha A, Jaber Samir, Kostrubiec Maciej, Lassau Nathalie, Laterre Pierre François, Lebreton Guillaume, Levitt Joseph E, Mebazaa Alexandre, Rubin Eileen, Sinha Pratik, Ware Lorraine B, Matthay Michael A
Abstract excerpt
The acute respiratory distress syndrome (ARDS) is a common critical illness syndrome with high morbidity and mortality. There are no proven pharmacological therapies for ARDS. The current definition of ARDS is based on shared clinical characteristics but does not capture the heterogeneity in clinical risk factors, imaging characteristics, physiology, timing of onset and trajectory, and biology of the syndrome....
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