Article
Analysis of CF patient survival confirms STAT3 as a CF-modifying gene with changing impact over time.
Human molecular genetics - 27 Jan 2023
Dunsche Inga, Raddatz Ellen L, Ismer Haide, Hedtfeld Silke, Tamm Stephanie, Moser Saskia, Kontsendorn Julia, Tümmler Burkhard, Janciauskiene Sabina, Dittrich Anna-Maria, Stanke Frauke
Abstract excerpt
INTRODUCTION AND AIM: The signal transducer and activator of transcription 3 (STAT3) has been identified as one of the cystic fibrosis (CF) modifying genes. In this study, we aimed to assess the association between STAT3 genotype and CF patient survival over several decades and to investigate the effect of STAT3 inhibition on epithelial CFTR expression. METHODS: We analyzed the informative genetic marker STAT3Sat...
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