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SLC19A1 Genetic Variation Leads to Altered Thiamine Diphosphate Transport: Implications for the Risk of Developing Wernicke-Korsakoff's Syndrome.

Alcohol and alcoholism (Oxford, Oxfordshire) - 10 Sept 2022

O'Brien Niamh L, Quadri Giorgia, Lightley Iain, Sharp Sally I, Guerrini Irene, Smith Iain, Heydtmann Mathis, Morgan Marsha Y, Thomson Allan D, Bass Nicholas J, McHugh Patrick C, McQuillin Andrew

Abstract excerpt

AIMS: Wernicke-Korsakoff syndrome (WKS) is commonly associated with chronic alcohol misuse, a condition known to have multiple detrimental effects on thiamine metabolism. This study was conducted to identify genetic variants that may contribute to the development of WKS in individuals with alcohol dependence syndrome through alteration of thiamine transport into cells. METHODS: Exome sequencing data from a panel...

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PMID: 35952336
DOI: 10.1093/alcalc/agac032

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