Article
Investigation of a common canine factor VII deficiency variant in dogs with unexplained bleeding on autopsy.
Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc - 1 Sept 2022
Clark Jessica A, Hooser Stephen B, Dreger Dayna L, Burcham Grant N, Ekenstedt Kari J
Abstract excerpt
The factor VII (FVII) protein is an integral component of the extrinsic coagulation pathway. Deleterious variants in the gene encoding this protein can result in factor VII deficiency (FVIID), a bleeding disorder characterized by abnormal (slowed) clotting with a wide range of severity, from asymptomatic to life-threatening. In canids, a single FVIID-associated variant, first described in Beagles, has been...
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