Article
Allele-biased expression of the bovine APOB gene associated with the cholesterol deficiency defect suggests cis-regulatory enhancer effects of the LTR retrotransposon insertion.
Scientific reports - 5 Aug 2022
Becker Doreen, Weikard Rosemarie, Heimes Annika, Hadlich Frieder, Hammon Harald M, Meyerholz Marie M, Petzl Wolfram, Zerbe Holm, Schuberth Hans-Joachim, Hoedemaker Martina, Schmicke Marion, Engelmann Susanne, Kühn Christa
Abstract excerpt
The insertion of an endogenous retroviral long terminal repeat (LTR) sequence into the bovine apolipoprotein B (APOB) gene is causal to the inherited genetic defect cholesterol deficiency (CD) observed in neonatal and young calves. Affected calves suffer from developmental abnormalities, symptoms of incurable diarrhoea and often die within weeks to a few months after birth. Neither the detailed effects of the LTR...
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