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Article

Diet-induced obesity impairs spermatogenesis: the critical role of NLRP3 in Sertoli cells

1 Aug 2022

Abstract excerpt

BACKGROUND: Accumulating evidence indicates a key role of Sertoli cell (SC) malfunction in spermatogenesis impairment induced by obesity. Nucleotide-binding oligomerization domain-like receptor with a pyrin domain 3 (NLRP3) is expressed in SCs, but the role of NLRP3 in the pathological process of obesity-induced male infertility remains unclear. METHODS: NLRP3-deficient mice were fed a high-fat diet for 24 weeks...

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PMID: 35915511
DOI: 10.1186/s41232-022-00203-z

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