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Alteration of the Gut Microbiome in Inflammatory Bowel Disease

28 Jul 2022

Abstract excerpt

BACKGROUND: Alteration of the gut microbial structure and function (dysbiosis) is associated with the pathogenesis of various disorders including inflammatory bowel disease (IBD). SUMMARY: Under normal conditions, β-oxidation of butyrate consumes oxygen in colonocytes and maintains the anaerobic environment in the lumen. Depletion of butyrate-producing bacteria results in anaerobic glycolysis in colonocytes and...

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PMID: 35901721
DOI: 10.1159/000525925

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