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Reporter Flaviviruses as Tools to Demonstrate Homologous and Heterologous Superinfection Exclusion

8 Jul 2022

Abstract excerpt

Binjari virus (BinJV) is a lineage II or dual-host affiliated insect-specific flavivirus previously demonstrated as replication-deficient in vertebrate cells. Previous studies have shown that BinJV is tolerant to exchanging its structural proteins (prM-E) with pathogenic flaviviruses, making it a safe backbone for flavivirus vaccines. Here, we report generation by circular polymerase extension reaction of BinJV...

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PMID: 35891480
DOI: 10.3390/v14071501

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