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Barriers to genetic manipulation of Enterococci: Current Approaches and Future Directions

26 Jul 2022

Abstract excerpt

Enterococcus faecalis and Enterococcus faecium are Gram-positive commensal gut bacteria that can also cause fatal infections. To study clinically relevant multi-drug resistant E. faecalis and E. faecium strains, methods are needed to overcome physical (thick cell wall) and enzymatic barriers that limit the transfer of foreign DNA and thus prevent facile genetic manipulation. Enzymatic barriers to DNA uptake...

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PMID: 35883217
DOI: 10.1093/femsre/fuac036

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