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Enhanced inflammation and suppressed adaptive immunity in COVID-19 with prolonged RNA shedding

25 Jul 2022

Abstract excerpt

Little is known regarding why a subset of COVID-19 patients exhibited prolonged positivity of SARS-CoV-2 infection. Here, we found that patients with long viral RNA course (LC) exhibited prolonged high-level IgG antibodies and higher regulatory T (Treg) cell counts compared to those with short viral RNA course (SC) in terms of viral load. Longitudinal proteomics and metabolomics analyses of the patient sera...

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PMID: 35879274
DOI: 10.1038/s41421-022-00441-y

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