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Article

Intratumor graph neural network recovers hidden prognostic value of multi-biomarker spatial heterogeneity

22 Jul 2022

Abstract excerpt

Biomarkers are indispensable for precision medicine. However, focused single-biomarker development using human tissue has been complicated by sample spatial heterogeneity. To address this challenge, we tested a representation of primary tumor that synergistically integrated multiple in situ biomarkers of extracellular matrix from multiple sampling regions into an intratumor graph neural network. Surprisingly, the...

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PMID: 35869055
DOI: 10.1038/s41467-022-31771-w

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