Article
A TP53 Related Immune Prognostic Model for the Prediction of Clinical Outcomes and Therapeutic Responses in Lung Adenocarcinoma.
Frontiers in immunology - 1 Jan 2022
Zhang Xiaonan, Min Simin, Yang Yifan, Ding Dushan, Li Qicai, Liu Saisai, Tao Tao, Zhang Ming, Li Baiqing, Zhao Shidi, Ge Rongjing, Yang Fan, Li Yan, He Xiaoyu, Ma Xiaoxiao, Wang Lian, Wu Tianyu, Wang Tao, Wang Guowen
Abstract excerpt
TP53 is the most frequently mutated gene in lung adenocarcinoma (LUAD). The tumor immune microenvironment (TIM) is considered a vital factor that influences tumor progression and survival rate. The influence of TP53 mutation on TIM in LUAD has not been fully studied. Here we systematically investigated the relationship and potential mechanisms between TP53 mutation status and immune response in LUAD. We...
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