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Article

Sofosbuvir induces gene expression for promoting cell proliferation and migration of hepatocellular carcinoma cells

12 Jul 2022

Abstract excerpt

Direct-acting antivirals (DAAs) have achieved a sustained virological response (SVR) rate of 95-99% in treating HCV. Several studies suggested that treatment with sofosbuvir (SOF), one type of DAAs, may be associated with increased risk of developing HCC. The aim of this study is to investigate the potential mechanisms of SOF on the development of HCC. OR-6 (harboring full-length genotype 1b HCV) and Huh 7.5.1...

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PMID: 35833210
DOI: 10.18632/aging.204170

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