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An integrative bioinformatics approach to decipher adipocyte-induced transdifferentiation of osteoblast

1 Jul 2022

Abstract excerpt

In human, bone loss is associated with increased marrow adipose tissue and recent data suggest that medullary adipocytes could play a role in osteoporosis by acting on neighboring bone-forming osteoblasts. Supporting this hypothesis, we previously showed, in a coculture model based on human bone marrow stromal cells, that factors secreted by adipocytes induced the conversion of osteoblasts towards an...

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PMID: 35817314
DOI: 10.1016/j.ygeno.2022.110422

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