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The Denaturant- and Mutation-Induced Disassembly of Pseudomonas aeruginosa Hexameric Hfq Y55W Mutant.

Molecules (Basel, Switzerland) - 14 Jun 2022

Marchenkov Victor, Lekontseva Natalia, Marchenko Natalia, Kashparov Ivan, Murina Victoriia, Nikulin Alexey, Filimonov Vladimir, Semisotnov Gennady

Abstract excerpt

Although oligomeric proteins are predominant in cells, their folding is poorly studied at present. This work is focused on the denaturant- and mutation-induced disassembly of the hexameric mutant Y55W of the Qβ host factor (Hfq) from mesophilic Pseudomonas aeruginosa (Pae). Using intrinsic tryptophan fluorescence, dynamic light scattering (DLS), and high-performance liquid chromatography (HPLC), we show that the...

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Identifiers

PMID: 35744948
DOI: 10.3390/molecules27123821
PMCID: PMC9228748

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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