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Tideglusib promotes wound healing in aged skin by activating PI3K/Akt pathway

21 Jun 2022

Abstract excerpt

BACKGROUND: Aging disturbs the skin morphology and function, manifested as thinned epithelium and impaired wound healing. As a major type of skin cells, epidermal stem cells (EpiSCs) are inevitably affected by aging. The effect of age on EpiSCs and wound healing needs to be further explored. METHODS: Skin RNA-seq data of young (5 months) and old (30 months) CB6F1 mice were obtained from GEO Series GSE35322 with...

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PMID: 35729652
DOI: 10.1186/s13287-022-02949-2

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