Article
Efficacy and Safety of Befotertinib (D-0316) in Patients With EGFR T790M-Mutated NSCLC That Had Progressed After Prior EGFR Tyrosine Kinase Inhibitor Therapy: A Phase 2, Multicenter, Single-Arm, Open-Label Study.
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer - 1 Oct 2022
Lu Shun, Zhang Yiping, Zhang Guojun, Zhou Jianying, Cang Shundong, Cheng Ying, Wu Gang, Cao Peiguo, Lv Dongqing, Jian Hong, Chen Chengshui, Jin Xiangming, Tian Panwen, Wang Kai, Jiang Guanming, Chen Gongyan, Chen Qun, Zhao Hui, Ding Cuimin, Guo Renhua, Sun Guoping, Wang Bin, Jiang Liyan, Liu Zhe, Fang Jian, Yang Junquan, Zhuang Wu, Liu Yunpeng, Zhang Jian, Pan Yueyin, Chen Jun, Yu Qitao, Zhao Min, Cui Jiuwei, Li Dianming, Yi Tienan, Yu Zhuang, Yang Yan, Zhang Yan, Zhi Xiuyi, Huang Yunchao, Wu Rong, Chen Liangan, Zang Aimin, Cao Lejie, Li Qingshan, Li Xiaoling, Song Yong, Wang Donglin, Zhang Shucai, Ding Lieming, Zhang Ling, Yuan Xiaobin, Yao Lin, Shen Zhilin
Abstract excerpt
INTRODUCTION: Befotertinib (D-0316) is a novel, third-generation EGFR tyrosine kinase inhibitor (TKI). This study evaluated befotertinib in patients with locally advanced or metastatic NSCLC who developed an EGFR T790M mutation after progression on first- or second-generation EGFR TKI therapy. METHODS: This was a single-arm, open-label, phase 2 study at 49 hospitals across mainland China. Patients with locally...
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