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Systematic Analysis of Actively Transcribed Core Matrisome Genes Across Tissues and Cell Phenotypes.

Matrix biology : journal of the International Society for Matrix Biology - 1 Aug 2022

Tellman Tristen V, Dede Merve, Aggarwal Vikram A, Salmon Duncan, Naba Alexandra, Farach-Carson Mary C

Abstract excerpt

The extracellular matrix (ECM) is a highly dynamic, well-organized acellular network of tissue-specific biomolecules, that can be divided into structural or core ECM proteins and ECM-associated proteins. The ECM serves as a blueprint for organ development and function and, when structurally altered through mutation, altered expression, or degradation, can lead to debilitating syndromes that often affect one...

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PMID: 35714875
DOI: 10.1016/j.matbio.2022.06.003

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