Article
A multi-population phenome-wide association study of genetically-predicted height in the Million Veteran Program.
PLoS genetics - 1 Jun 2022
Raghavan Sridharan, Huang Jie, Tcheandjieu Catherine, Huffman Jennifer E, Litkowski Elizabeth, Liu Chang, Ho Yuk-Lam A, Hunter-Zinck Haley, Zhao Hongyu, Marouli Eirini, North Kari E, Lange Ethan, Lange Leslie A, Voight Benjamin F, Gaziano J Michael, Pyarajan Saiju, Hauser Elizabeth R, Tsao Philip S, Wilson Peter W F, Chang Kyong-Mi, Cho Kelly, O'Donnell Christopher J, Sun Yan V, Assimes Themistocles L
Abstract excerpt
BACKGROUND: Height has been associated with many clinical traits but whether such associations are causal versus secondary to confounding remains unclear in many cases. To systematically examine this question, we performed a Mendelian Randomization-Phenome-wide association study (MR-PheWAS) using clinical and genetic data from a national healthcare system biobank. METHODS AND FINDINGS: Analyses were performed...
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