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Article

Master microRNA-222 regulates cardiac microRNA maturation and triggers Tetralogy of Fallot

30 May 2022

Abstract excerpt

Tetralogy of Fallot (TOF) is the most common complex congenital heart disease. Besides gene mutations and copy number variants, altered protein function induced by post-transcriptional or translational regulation also contributes to the onset of TOF. 1 MiRNAs are short noncoding RNAs that bind to the 3’-UTR of target mRNAs to repress protein production. However, the causal link between miRNAs and TOF and the...

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PMID: 35644810
DOI: 10.1038/s41392-022-00993-1

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