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Depletion of Toxoplasma adenine nucleotide translocator leads to defects in mitochondrial morphology

31 May 2022

Abstract excerpt

BACKGROUND: Adenine nucleotide translocase (ANT) is a protein that catalyzes the exchange of ADP/ATP across the inner mitochondrial membrane. Beyond this, ANT is closely associated with cell death pathways and mitochondrial dysfunction. It is a potential therapeutic target for many diseases. The function of the ANT in Toxoplasma gondii is poorly understood. METHODS: The CRISPR/CAS9 gene editing tool was used to...

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PMID: 35642006
DOI: 10.1186/s13071-022-05295-7

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