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Common single-nucleotide polymorphisms combined with a genetic risk score provide new insights regarding the etiology of gestational diabetes mellitus.

Diabetic medicine : a journal of the British Diabetic Association - 1 Aug 2022

Fang Xiangnan, Jin Li, Tang Mengyang, Lu Wenqian, Lai Siyu, Zhang Rong, Zhang Hong, Jiang Feng, Luo Mingjuan, Hu Cheng

Abstract excerpt

AIMS: Few studies have constructed a genetic risk score (GRS) to predict the risk of gestaional diabetes mellitus (GDM). We tested the hypothesis that single-nucleotide polymorphisms (SNPs) confirmed for diabetes and obesity and the GRS are associated with GDM. METHODS: We conducted a case-control study comprising 971 GDM cases and 1682 controls from the University of Hong Kong Shenzhen Hospital. A total of 1448...

Topics

Female
Humans
Pregnancy
Case-Control Studies
Diabetes Mellitus, Type 1
Diabetes Mellitus, Type 2
Diabetes, Gestational
Genetic Predisposition to Disease
Obesity
Polymorphism, Single Nucleotide

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 35587197
DOI: 10.1111/dme.14885

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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