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MiR-25 blunts autophagy and promotes the survival of Mycobacterium tuberculosis by regulating NPC1

22 Apr 2022

Abstract excerpt

(Mtb) evades host clearance by inhibiting autophagy. MicroRNA-25 (miR-25) expression was significantly up-regulated in the lung tissues of mice infected with Bacillus Calmette-Guerin (BCG) and macrophages infected with Mtb or BCG, especially in the early stages of infection. MiR-25 can significantly increase the survival of Mtb and BCG in macrophages. We validated that miR-25 targets the NPC1 protein located on...

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PMID: 35586071
DOI: 10.1016/j.isci.2022.104279

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