Article
AENEAS: A Randomized Phase III Trial of Aumolertinib Versus Gefitinib as First-Line Therapy for Locally Advanced or MetastaticNon-Small-Cell Lung Cancer With EGFR Exon 19 Deletion or L858R Mutations.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 20 Sept 2022
Lu Shun, Dong Xiaorong, Jian Hong, Chen Jianhua, Chen Gongyan, Sun Yuping, Ji Yinghua, Wang Ziping, Shi Jianhua, Lu Junguo, Chen Shaoshui, Lv Dongqing, Zhang Guojun, Liu Chunling, Li Juan, Yu Xinmin, Lin Zhong, Yu Zhuang, Wang Zhehai, Cui Jiuwei, Xu Xingxiang, Fang Jian, Feng Jifeng, Xu Zhi, Ma Rui, Hu Jie, Yang Nong, Zhou Xiangdong, Wu Xiaohong, Hu Chengping, Zhang Zhihong, Lu You, Hu Yanping, Jiang Liyan, Wang Qiming, Guo Renhua, Zhou Jianying, Li Baolan, Hu Chunhong, Tong Wancheng, Zhang Helong, Ma Lin, Chen Yuan, Jie Zhijun, Yao Yu, Zhang Longzhen, Jie Weng, Li Weidong, Xiong Jianping, Ye Xianwei, Duan Jianchun, Yang Haihua, Sun Meili, Sun Changan, Wei Hongying, Li Chuan, Ali Siraj M, Miller Vincent A, Wu Qiong
Abstract excerpt
PURPOSE: Aumolertinib (formerly almonertinib; HS-10296) is a novel third-generation epidermal growth factor receptor tyrosine kinase inhibitor approved in China. This double-blind phase III trial evaluated the efficacy and safety of aumolertinib compared with gefitinib as a first-line treatment for locally advanced or metastatic EGFR-mutated non-small-cell lung cancer (NSCLC; ClinicalTrials.gov identifier:...
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