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Obesity Affects the Proliferative Potential of Equine Endometrial Progenitor Cells and Modulates Their Molecular Phenotype Associated with Mitochondrial Metabolism.

Cells - 24 Apr 2022

Smieszek Agnieszka, Marcinkowska Klaudia, Pielok Ariadna, Sikora Mateusz, Valihrach Lukas, Carnevale Elaine, Marycz Krzysztof

Abstract excerpt

The study aimed to investigate the influence of obesity on cellular features of equine endometrial progenitor cells (Eca EPCs), including viability, proliferation capacity, mitochondrial metabolism, and oxidative homeostasis. Eca EPCs derived from non-obese (non-OB) and obese (OB) mares were characterized by cellular phenotype and multipotency. Obesity-induced changes in the activity of Eca EPCs include the...

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PMID: 35563743
DOI: 10.3390/cells11091437
PMCID: PMC9100746

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