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Single-cell–resolution map of human retinal pigment epithelium helps discover subpopulations with differential disease sensitivity

6 May 2022

Abstract excerpt

Regional phenotypic and functional differences in the retinal pigment epithelium (RPE) monolayer have been suggested to account for regional susceptibility in ocular diseases such as age-related macular degeneration (AMD), late-onset retinal degeneration (L-ORD), and choroideremia (CHM). However, a comprehensive description of human topographical RPE diversity is not yet available, thus limiting the understanding...

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PMID: 35522714
DOI: 10.1073/pnas.2117553119

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