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Article

Mobocertinib Dose Rationale in Patients with Metastatic NSCLC with EGFR Exon 20 Insertions: Exposure-Response Analyses of a Pivotal Phase I/II Study.

Clinical pharmacology and therapeutics - 1 Aug 2022

Gupta Neeraj, Largajolli Anna, Witjes Han, Diderichsen Paul M, Zhang Steven, Hanley Michael J, Lin Jianchang, Mehta Minal

Abstract excerpt

Mobocertinib is an oral tyrosine kinase inhibitor approved for treatment of patients with locally advanced or metastatic non-small cell lung cancer (mNSCLC) with epidermal growth factor receptor gene (EGFR) exon 20 insertion (ex20ins) mutations previously treated with platinum-based chemotherapy. These exposure-response analyses assessed potential relationships between exposure and efficacy or safety outcomes in...

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Identifiers

PMID: 35467009
DOI: 10.1002/cpt.2622
PMCID: PMC9540490

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