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Article

Novel patient‐derived xenograft and cell line models for therapeutic screening in NF2 ‐associated schwannoma

8 Apr 2022

Abstract excerpt

Treatment of schwannomas in patients with neurofibromatosis type 2 (NF2) is extremely unsatisfactory, and innovative therapeutic approaches are urgently needed. However, the lack of clinically relevant NF2-associated schwannoma models has severely hampered drug discovery in this rare disease. Here we report the first establishment and characterization of patient-derived xenograft (PDX) and cell line models of...

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PMID: 35394061
DOI: 10.1002/path.5908

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