Article
Mapping anorexia nervosa genes to clinical phenotypes.
Psychological medicine - 1 Apr 2023
Johnson Jessica S, Cote Alanna C, Dobbyn Amanda, Sloofman Laura G, Xu Jiayi, Cotter Liam, Charney Alexander W, Birgegård Andreas, Jordan Jennifer, Kennedy Martin, Landén Mikaél, Maguire Sarah L, Martin Nicholas G, Mortensen Preben Bo, Thornton Laura M, Bulik Cynthia M, Huckins Laura M
Abstract excerpt
BACKGROUND: Anorexia nervosa (AN) is a psychiatric disorder with complex etiology, with a significant portion of disease risk imparted by genetics. Traditional genome-wide association studies (GWAS) produce principal evidence for the association of genetic variants with disease. Transcriptomic imputation (TI) allows for the translation of those variants into regulatory mechanisms, which can then be used to assess...
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