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Article

Prophylactic effects of hyperforin on anhedonia-like phenotype in chronic restrain stress model: A role of gut microbiota.

Letters in applied microbiology - 1 Nov 2022

Zhang Zheng, Yao Chuan, Li Min, Wang Li-Chuang, Huang Wei, Chen Qing-Jie

Abstract excerpt

Anhedonia is the core symptom of depression, which largely reflects the therapeutic effect of depression. Hypericum perforatum is one of the most important antidepressant herb that has fewer side effects than traditional antidepressants. Considering the antibacterial effect of Hypericum perforatum, we verified whether this antidepressant activity was related to intestinal microbiomics. So we established anhedonia...

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PMID: 35348232
DOI: 10.1111/lam.13710

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