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Article

Evolution of germline TP53 variant classification in children with cancer.

Cancer genetics - 1 Jun 2022

Tallis E, Scollon S, Ritter D I, Plon S E

Abstract excerpt

Li-Fraumeni syndrome, caused by germline pathogenic variants in TP53, results in susceptibility to multiple cancers. Variants of uncertain significance (VUS) and reclassification of variants over time pose management concerns given improved survival with cancer surveillance for LFS patients. We describe the experience of TP53 variant reclassification at a pediatric cancer center. METHODS: We reviewed medical...

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Identifiers

PMID: 35306447
DOI: 10.1016/j.cancergen.2022.02.011
PMCID: PMC9133135

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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