Article
Obesity phenotype induced by high-fat diet leads to maternal-fetal constraint, placental inefficiency, and fetal growth restriction in mice.
The Journal of nutritional biochemistry - 1 Jun 2022
Sanches Ana Paula Varela, de Oliveira Josilene Lopes, Ferreira Maíra Schuchter, Lima Bruna de Souza, Miyamoto Josiane Érica, Simino Laís Angélica de Paula, Torsoni Márcio Alberto, Torsoni Adriana Souza, Milanski Marciane, Ignácio-Souza Letícia
Abstract excerpt
The aim of this study was to investigate certain parameters regarding the maternal-fetal outcomes in a diet-induced obesity model. Obese, glucose-intolerant females who were exposed to a high-fat diet prior to pregnancy had lower placental efficiency and lower birth weight pups compared to the controls. Simple linear regression analyses showed that maternal obesity disrupts the proportionality between maternal...
Topics
- Animals
- Diet, High-Fat
- Female
- Fetal Development
- Fetal Growth Retardation
- Glucose
- Humans
- Mice
- Obesity
- Pregnancy in Obesity