Role of mobile genetic elements in the global dissemination of the carbapenem resistance gene blaNDM

Abstract excerpt

Abstract The mobile resistance gene bla NDM encodes the NDM enzyme which hydrolyses carbapenems, a class of antibiotics used to treat some of the most severe bacterial infections. The bla NDM gene is globally distributed across a variety of Gram-negative bacteria on multiple plasmids, typically located within highly recombining and transposon-rich genomic regions, which leads to the dynamics underlying the global...

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