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Thyroid function, pernicious anemia and erythropoiesis: a two-sample Mendelian randomization study

25 Feb 2022

Abstract excerpt

Autoimmune thyroid disease (AITD) and pernicious anemia (PA) often coexist, but the directionality is unknown. In a two-sample Mendelian randomization (MR) analysis, using summary statistics from large genome-wide association studies (GWASs) in Europeans (N = 49 269-755 406), we examined the genetic associations between thyroid function, PA and markers of erythropoiesis. We performed inverse variance weighted...

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PMID: 35225327
DOI: 10.1093/hmg/ddac052

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