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Article

In Vitro Models for the Evaluation of Antisense Oligonucleotides in Skin.

Methods in molecular biology (Clifton, N.J.) - 1 Jan 2022

Bremer Jeroen, van den Akker Peter C

Abstract excerpt

The genodermatosis dystrophic epidermolysis bullosa (DEB) is caused by mutations in the COL7A1 gene which encodes type VII collagen (C7). In the cutaneous basement membrane zone, C7 secures attachment of the epidermal basal keratinocyte to the papillary dermis by means of anchoring fibril formation. The complete absence of these anchoring fibrils leads to severe blistering of skin and mucosa upon the slightest...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Oligonucleotides, Antisense

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Identifiers

PMID: 35213017
DOI: 10.1007/978-1-0716-2010-6_11
PMCID: PMC9703231

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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In Vitro Models for the Evaluation of Antisense Oligonucleotides in Skin.PMID 35213017Read ↗

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Therapeutic Prospects of Exon Skipping for Epidermolysis Bullosa.Semantic proximity Read ↗

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