Article
Extended familial risk of suicide death is associated with younger age at death and elevated polygenic risk of suicide.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 1 Apr 2022
Coon Hilary, Shabalin Andrey, Bakian Amanda V, DiBlasi Emily, Monson Eric T, Kirby Anne, Chen Danli, Fraser Alison, Yu Zhe, Staley Michael, Callor William Brandon, Christensen Erik D, Crowell Sheila E, Gray Douglas, Crockett David K, Li Qingqin S, Keeshin Brooks, Docherty Anna R
Abstract excerpt
Suicide accounts for >800,000 deaths annually worldwide; prevention is an urgent public health issue. Identification of risk factors remains challenging due to complexity and heterogeneity. The study of suicide deaths with increased extended familial risk provides an avenue to reduce etiological heterogeneity and explore traits associated with increased genetic liability. Using extensive genealogical records, we...
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